Review Paper:
Zebrafish as a
fascinating animal model: a robust platform for in vivo screening for biomedical
researches
Dubey Anubhav, Kumari Mamta, Sahu Vikram Kumar, Mishra Amit and Dash Sribatsa Lanchhana
International Journal of Agricultural Sciences and
Veterinary Medicine;
Vol. 12(1); 34-39;
doi: https://doi.org/10.25303/1201ijasvm034039; (2024)
Abstract
Due to its striking similarities in anatomy, physiology and genetics with humans,
the zebrafish (Danio rerio), a little tropical freshwater fish, has seen massive
adoption as a model. Thus, zebrafish are a great model to study human disease mechanisms
in the areas of toxicology, genetics and behaviour. Due to its shared vascular system,
musculature, renal system and ocular structures with humans, the zebrafish is classified
as a vertebrate. Because of the striking similarities between the human genome and
that of zebrafish including the arrangement of genes and the pathways that regulate
signal transduction, zebrafish might one day be used to simulate human illnesses.
There are many screening models present for the determination of preclinical screening
activity of the drug molecule.
The main objective of this study is to find at which model is best having low cost.
A literature search was conducted on the databases namely Science direct and PubMed
with the help of different keywords such as "Zebrafish", "In vitro models" and "In
vivo models". The search was customized by applying the appropriate filters so as
to get the most relevant articles to meet the objective of this review article:
There were different research and review papers based on the Zebrafish models for
the determination of different activity of new drug molecules. We found some useful
models for the different activity of drugs and suggested that, if we used different
methods together, then we may obtain the most relevant result in our research area.
