Review Paper:
Pharmacological
significance of Oxadiazole scaffold
Santhanalakshmi K., Margandan K., Manivannan P. and Jacquline Rosy P.
Res. J. Chem. Environ; Vol. 25(8); 177-188;
doi: https://doi.org/10.25303/258rjce177188; (2021)
Abstract
Heterocycles come under an important branch of organic chemistry that contains at
least one atom other than carbon as a part of ring system. The most common hetero
atoms that are widely used are nitrogen, oxygen and sulphur. In synthetic organic
chemistry, synthesis of heterocyclic compound is of immense interest due to its
therapeutic applications and their existence in several natural products like vitamins,
hormones, antibiotics and alkaloids. The oxadiazole nucleus is one of the most significant
and well known heterocyclic compounds due to its broad range of pharmacological
and therapeutic activities like anti-depressant, anticonvulsant, anti-proliferate,
anti-fungal, antiinflammatory, anti-cancer, anti-HIV, insecticidal, antimiotic,
herbicidal, hypoglycemic and muscle relaxant etc.
The wide and potent activities of oxadiazole and their derivatives have established
them as pharmacologically significant scaffolds. The basic heterocyclic rings present
in the several medicinal agents are 1,2,3-oxadiazole, 1,2,4- oxadiazole, 1,2,5-
oxadiazole and 1, 3, 4- oxadiazole. Research has focused on oxadiazole and their
derivatives to prove the pharmacological importance of heterocyclic nucleus. The
present review will summarize the pharmacological activities reported for oxadiazole
derivatives.
