In vitro antioxidant
and antimicrobial activity of isolated flavonoid from the methanolic extract of
Andrographis echioides leaves
Durgadevi S. and Leema Rose A.
Res. J. Chem. Environ; Vol. 27(6); 67-73;
doi: https://doi.org/10.25303/2706rjce067073; (2023)
Abstract
The aim of this study was to isolate the active flavonoid component found in the
entire Andrographis echioides plant. The isolation of flavonoids from a plant component
was investigated using a methanolic extract from the leaves of A.echioides. The
presence of flavonoid components in methanol extract was identified by phytochemical
studies. TLC and column chromatography were used to purify the flavonoid component
that had been isolated. UV-Visible, FT-IR, C13, H1NMR and Mass spectroscopy were
used to characterize the structures of the isolated compounds.
As a result, the isolated molecule was named 9-methoxy-6a, 11a-dihydro-6H-benzofuro
[3, 2-C chromen-3-ol] i.e. medicarpin. For the isolated flavonoid found in this
plant, additional biological research is required. Flavonoids are a unique group
of secondary metabolites found in plants that have been utilized as traditional
remedies with scientifically confirmed pharmacological advantages. They support
a wide range of medical actions that could lead to unique and potentially therapeutic
findings in drug development. Recent study has focused on flavonoids functional
activity as antioxidants in the presence of oxidative stress.
