A study of in
vitro antimicrobial activities and antioxidant of lanthanide complexes with a tri
dentate Schiff base ligand
Nagaraju N., Sreeramulu J., Anjaneyulu V., Malleswarareddy P. and Ramamohan G.
Res. J. Chem. Environ; Vol. 27(5); 42-51;
doi: https://doi.org/10.25303/2705rjce042051; (2023)
Abstract
The tridentate N3-type Schiff base 4-(anthracen-10-yl)-2,6-di(pyridin-2-yl)pyridine
was synthesized from the condensation reaction of 2-acetyl pyridine and anthracene-10-carbaldehyde
with ammonia using one pot methodology. This hybrid ligand was used for synthesis
of lanthanide complexes (La, Sm and Eu) as novel potential biological agent. The
lanthanide complexes were characterized on the basis of elemental, FT-IR, UV-Visible,
mass spectrometry as well as molar conductivity. The complexes were screened for
in vitro antibacterial and antifungal activities against the multidrug resistant
pathogens such as Escherichia coli, Staphylococcus aureus and Aspergillus niger.
The antimicrobial results revealed that Sm+3 complex has a good potency against
different gram positive and gram negative bacteria in comparison with other complexes.
All lanthanide complexes showed a moderate antioxidant activity with IC50. The DPPH·
radical scavenging effects of the Schiff base ligand and its Ln (III) complexes
were screened. The Ln (III) complexes were significantly more efficient in quenching
DPPH· than the free Schiff base ligand.
