Novel amide functionalized
pyridine derivatives and their anticancer activity and molecular docking studies
Bhoomandla Srinu, Pandiri Sreedhar, Basireddy Sravanthi, Gundla Rambabu, Velavalapalli
Vani Madhuri, Venishetty Sunil Kumar and Kanuparthy Phani Raja
Res. J. Chem. Environ; Vol. 27(5); 65-72;
doi: https://doi.org/10.25303/2705rjce065072; (2023)
Abstract
A series of novel amide functionalized trifluoromethyl substituted pyridine derivatives
were prepared starting from pyridine 1 on reaction with bromoethylacetate followed
by reaction with different primary aliphatic amines, cyclic secondary amines or
L-amino acids under different set of conditions.
All the synthesized compounds 4a-j and 5a-d were screened for anticancer activity
against four cancer cell lines such as HeLa-Cervical cancer (CCL-2), COLO 205-Colon
cancer (CCL-222) HepG2- Liver cancer (HB-8065), MCF7-Breast cancer (HTB-22). 4j
and 5d showed good activity.
