Review Paper:
A novel approach
of 19F NMR based sensor
Khandelwal Amit Kumar, Hariyani Poonam and Shrivastava Barkha
Res. J. Chem. Environ; Vol. 27(9); 134-144;
doi: https://doi.org/10.25303/2709rjce1340144; (2023)
Abstract
Reliable and precise methods are to be applied ranging from biological field to
diagnosis and quality control to identify target analytes in samples. Nuclear magnetic
resonance (NMR) is a strongly recommended process that is suitable for collecting
data multidimensionally at molecular and atomic levels. Information obtained from
the NMR technique provides molecular structures, molecular interactions, dynamic
and diffusional properties of molecules. Overlapping of NMR signals of each component
makes it difficult to interpret data and low sensitivity makes it unfitting for
many samples with a low concentration of analytes.
These limitations can be rectified by adding heteronuclear specially designed sensors,
inventive transduction mechanism and strong pulse sequences. 19F NMR tool is extensively
accepted method to detect the interactions among a variety of biological substrates
with 19F-isotopic species. This review includes the detection of biomolecules, mainly
enzymes and enzymatic reactions based on sensor applicability.
