New 1, 2, 3-triazole-Furan
Scaffold Schiff bases: Design, Synthesis, Characterization and biological studies
Somanatha T.M., Krishnaswamy G., Nayana R., Nayana J., Bhavana R., Shivaraj G.,
Sreenivasa S. and Shet Prakash M.
Res. J. Chem. Environ; Vol. 27(9); 1-7;
doi: https://doi.org/10.25303/2709rjce0107; (2023)
Abstract
In the present investigation, Schiff bases (SBs) bearing 1, 2, 3-triazole and furan
motif were synthesized through condensation reaction via conventional approach (Route-A)
and solvent free approach (Route-B). It has been found that route-B is efficient
since it is eco friendly with short reaction time and satisfactory yield than route-A.
The structure and formation of targeted Schiff bases (SBs) were confirmed by different
spectroscopic techniques (1H NMR, 13C NMR and Mass). Finally, in vitro antimicrobial
screening result revealed that the synthesised SBs derivatives may act as moderate
antimicrobial agents.
