Synthesis, antimicrobial
activity and molecular docking study of (e)-4-(4-((3-benzylidene-2-oxoindolin-1-yl)
methyl)-1h-1,2,3-triazol-1-yl)benzoic acid derivatives
Chittimalla Srinivasulu, Pochampally Jalapathi, Thumma Vishnu, Nalla Umapathi and
Matta Raghavender
Res. J. Chem. Environ; Vol. 27(9); 39-45;
doi: https://doi.org/10.25303/2709rjce039045; (2023)
Abstract
A series of (E)-1-((1-aryl-1H-1,2,3-triazol-4-yl) methyl)-3-(arylmethylene)indolin-2-ones
was synthesised starting from commercially available indolin-2-one by the reaction
with aldehydes, propargyl bromide and finally benzoic acid azides. All the synthesized
1,2,3-triazole derivatives structure were characterized by IR, 1HNMR, 13CNMR and
mass spectrometry.
The synthesized compounds were evaluated for their in vitro antimicrobial activity
and their molecular docking studied with comparison of Oseltamivir drug into the
active pocket of neuraminidase.
