Proposal, Synthesis
and Antimicrobial activity of 1-((1-phenyl-1H-1,2,3-triazol-5-yl)methyl)-2-(4-phenyl-2H-chromen-3-yl)-1H-benzo[d]imidazole
Raghuramarao Irigineni, Krishnakanth Reddy L. and Kishore Babu B.
Res. J. Chem. Environ.; Vol. 28(5); 52-59;
doi: https://doi.org/10.25303/285rjce052059; (2024)
Abstract
A new series of 1-((1-phenyl-1H-1,2,3-triazol-5-yl) methyl)-2-(4-phenyl-2H-chromen-3-yl)-1H-benzo
[d] imidazole (12a-n) and a library of novel imidazole-1,2,3-triazole hybrids were
designed and synthesized based on the fusion pharmacophore approach. Therefore,
copper (I) catalyzed click reaction of propargylated imidazole with numerous organo
arylazides yielded imidazole-1,2,3-triazole hybrids 12a–n. The products were purified
over column chromatography and structures of these compounds are recognized by IR,
1H-NMR, 13C-NMR and mass spectral data.
All the final compounds were screened for their anti-microbial activity and the
effects were matched with ciprofloxacin. Compound (12d, l, i) was the most effective
compound of this series and with activities improved than ciprofloxacin under the
experienced situations. Chroman-4-one scaffold is a stable structure in heterocyclic
chemistry and drug conclusion.
