In vitro anti
diabetic activity of PVA encapsulated silver nanoparticles of ethanolic extract
of Pisonia grandis leaves
Veena G.O., Gayathri Devi S., Shubashini K. Sripathi and Vasundhara C.C.S.
Res. J. Biotech.; Vol. 20(4); 50-60;
doi: https://doi.org/10.25303/204rjbt050060; (2025)
Abstract
Diabetes mellitus is a chronic metabolic ailment that progresses beyond a person's
lifetime. It is brought on by a relative shortage of insulin synthesis, leading
to variable degrees of insulin resistance. The present study involves biosynthesis
of poly vinyl alcohol (PVA) encapsulated silver nanoparticles of ethanolic extract
of Pisonia grandis leaves (PVA AgNPs Pg) along with the evaluation of their potential
biomedical applications. Analytical techniques like UV spectroscopy, XRD, SEM, EDX,
TEM, FTIR and Zeta potential measurement were employed to assess the separated silver
nanoparticles. PVA AgNPs Pg was also used to investigate the anti-diabetic effect
in vitro.
These studies have showed significant efficacy in inhibiting the enzymes DPPIV,
alpha-amylase and alpha-glucosidase. Therefore, it is reasonable to conclude that
silver nanoparticles fabricated by green synthesis might be used as a phytomedicine
to treat diabetes.
