A pilot study
on Phthalates in Type 2 Diabetes Mellitus (T2DM) patients of South India
Nithya K.V., Mohite Ramakant, Babu J. Kiran, Elaiyaraja Arun, Ravindranath Venkatesan,
Jayaraman Yuvaraj, Perumal Vanamail and Gomathinayagam Rohini
Res. J. Biotech.; Vol. 20(8); 9-16;
doi: https://doi.org/10.25303/208rjbt09016; (2025)
Abstract
Phthalate esters (PAE), the commonly used low volatile, stable plasticizer pollutants
are strongly being associated with human pathogenesis. Understanding the regional
exposure and determining the influence of PAEs in T2DM enable prevention of T2DM
incidence and better disease management. The present study aimed to determine the
circulating concentrations of PAEs in a pilot population of healthy volunteers,
T2DM patients of South India using standardized GC MS based methods. The study results
indicated that in the study population, the BMI of the T2DM patients was significantly
higher (p<0.01) than the healthy volunteers and among the phthalate esters, DEHP
levels of the T2DM patients were significantly higher (p<0.05).
Further assessment of the phthalate esters among the male and female study population
indicated that the DBP levels were significantly higher (p<0.05) in the male population
of healthy volunteers and DEHP levels were significantly higher (p<0.05) in the
male study population when compared to the females. Detailed and large cohort studies
will bring to light the influence of PAEs, in particular DEHP and its association
with T2DM in the Indian/South Indian population.
