Characterizing
ADME/T and Physicochemical Properties of Bioactive Compounds from Manila Tamarind
for Therapeutic Insights
Tungal Soumya, Dongre Nilima, Devaranavadagi Basavaraj B. and Parvatikar Prachi
Res. J. Biotech.; Vol. 20(12); 265-273;
doi: https://doi.org/10.25303/2012rjbt2650273; (2025)
Abstract
Medicinal plants have been utilised in traditional medicine for centuries, providing
healthcare to 80% of the global population. Manila tamarind (Pithecellobium dulce)
is an underutilised plant with limited study into its therapeutic uses. This work
is to investigate the physicochemical features and therapeutic potential of bioactive
compounds from Pithecellobium dulce using computational drug analysis databases.
A total of 38 active phytocompounds were found through a comprehensive analysis
of plant bioactive chemicals based on a literature survey. Additionally, the physicochemical
characteristics and toxicity of these compounds with therapeutic advantages were
examined using computational databases such as PubChem and Swiss ADME/T, Boiled
egg, Bio-radar.
Manila tamarind (P. dulce) components contain phenols, flavonoids, saponins, and
other compounds. Furthermore, these chemicals have been shown to be effective in
the management of health benefits. The study highlights P. dulce as a valuable medicinal
plant due to its wide variety of biologically active compounds with nutraceutical
properties. However, further clinical research is necessary to confirm its therapeutic
applications and potential for commercial use.
