Inhibitory potential
of bioactive compounds from Pedalium murex L. extract against 1E9Z protein of Helicobacter
pylori
Abarna Ramananthatheerthan, Sugapriya Dhanasekaran, Alagumanikumaran Nagarajan and
Kannan Marikani
Res. J. Biotech.; Vol. 20(12); 101-108;
doi: https://doi.org/10.25303/2012rjbt1010108; (2025)
Abstract
Traditional medicine makes use of a variety of bioactive substances that are present
in medicinal plants. Pedalium murex L. ability to combat common diseases was investigated.
It included initial phytochemical investigations. Antibacterial and antioxidant
activity was expressed in a dose-dependent manner. Another primary emphasis of the
current study was the GC-MS analysis and Molecular Docking method of the ethanolic
extract of Pedalium murex L. leaves. The mass spectra of the 40 phytocomponents
of Pedalium murex L. matched with the National Institute of Standards and Technology
(NIST) Library, to identify the active compounds.
The potential of the chosen compounds was analysed against Helicobacter pylori’s
1E9Z. The chemical with the highest binding affinity against Helicobacter pylori
virulence component Vac A was identified through Docking research.
