Antibacterial
Activity, Phytochemical Analysis and GC-MS Investigation of Tephrosia purpurea linn
Plant Extracts against clinical pathogens
Kanmani Kannan, Sathyabama Narayanan, Radhakrishanan Natarajan and Sankareswaran
Muruganantham
Res. J. Biotech.; Vol. 20(2); 86-91;
doi: https://doi.org/10.25303/202rjbt086091; (2025)
Abstract
The present study of Tephrosia purpurea linn belongs to the family Leguminosa (Fabaceae)
screened for secondary metabolites to evaluate its antimicrobial activities using
standard procedures. The whole extract with decreasing polarity (Methanol, Chloroform,
Petroleum ether, Hexane) was tested on Gram-negative and Gram-positive bacteria
like Staphylococcus aureus, proteus mirabilis, Escherichia coli, Salmonella typhi,
Klebsiella pneumonae, Pseudomonas aeruginosa. The same extract was tested against
Aspergillus niger and Candida albicans. The phytochemical analysis indicated the
presence of alkaloids, tannins and saponins in the whole extract of T. purpurea
Linn.
The result showed the whole extract of T. purpurea linn showing significant activity
against bacterial test models on comparing with the standard antibacterial like
amoxicillin and fluconazole. Antifungal activity was found even in different solvent
systems with increasing concentration. The ethanolic extract of T. purpurea contained
30 components, according to the results of GC-MS analysis The results reported in
the present work show evidence that the flower of T. purpurea Linn possesses antimicrobial
activity.
