Review Paper:
Preparation methods
and applications of Lipid-based nanosomes for advancement in the field of Pharmaceutical
Biotechnology: A review and outlook on future
Kamalan Kumaraguruparan Shrihari, Balashanmugam Dhanya, Kalidoss Amrutharani, Mohankumar
Nivethitha and Ilangovan Shanmuga Sundari
Res. J. Biotech.; Vol. 20(2); 202-221;
doi: https://doi.org/10.25303/202rjbt2020221; (2025)
Abstract
Nano-sized vesicles composed of a phospholipid bilayer encapsulating an aqueous
core called Liposomes, have garnered substantial attention in pharmaceutical biotechnology
for their capacity to safeguard and enhance drug and bioactive molecule delivery.
This review presents an overview of liposome preparation methods and their applications
in disease and gene therapy. Liposomes serve as drug delivery vehicles in cancer,
cardiovascular and infectious diseases. In cancer therapy, they precisely transport
chemotherapeutic agents to tumors, minimizing systemic toxicity. For cardiovascular
diseases, liposomes ferry nitric oxide and antioxidants, ameliorating vascular function
and reducing oxidative stress. In gene therapy, liposomes ferry nucleic acids (DNA,
RNA) to modulate gene expression. Targeting ligands like antibodies or peptides
further tailored liposomes for specific cell or tissue delivery.
With implications in diverse medical fields, particularly disease and gene therapy,
liposomes are versatile drug delivery systems. Their pharmacokinetic and pharmacodynamic
properties are shaped by preparation methods and composition. Advances have yielded
more stable and targeted liposomes. However, further exploration is required to
fully harness their potential, to ensure safer therapies and to tackle varied diseases.
In conclusion, liposomes hold promise in pharmaceutical applications, efficiently
delivering drugs and addressing therapeutic challenges. Continued research will
unlock their potential, revolutionizing patient care and medical practices.
