A meta-analysis
study: Vitamin D receptor genetic polymorphism in Respiratory tuberculosis
Sharma N., Khandelwal V. and Mohanty K.K.
Res. J. Biotech.; Vol. 20(1); 115-136;
doi: https://doi.org/10.25303/201rjbt1150136; (2025)
Abstract
Our study performed meta-analysis of all available literature on numerous features
of relation concerning vitamin D genetic polymorphisms and pulmonary tuberculosis.
PubMed and Springer databases were hunted and out of 365 articles, 40 studies were
chosen for the present review to examine the relation of PTB with vitamin D receptors
(VDR). A total of 18637 patients and 25515 controls, with 35 investigations on VDR
FokI polymorphism, 33 on VDR TaqI polymorphism, 25 on VDR BsmI polymorphism and
22 on VDR ApaI polymorphism were included. To understand the connection of polymorphisms
with Tuberculosis (TB) hazard, the odds ratios (ORs) and the conforming 95% confidence
intervals (CIs) were estimated rendering to the occurrences of genotypes. P values
of 0.05 were considered statistically relevant. Funnel maps were used to evaluate
publication bias.
Several published articles observed the relation of FokI, ApaI, BsmI and TaqI gene
polymorphism of VDR with pulmonary tuberculosis (PTB). Their outcomes were unpredictable;
hence we did a meta-analysis to find the precise relativeness of the four. Our findings
complement many studies being conducted on various communities across the world
to better understand the significance of VDR polymorphism in PTB. FokI, TaqI and
ApaI showed risk and TaqI showed no risk of PTB development in the population. Depleted
amounts of vitamin D were seen in TB patients. Our analysis exposed the relation
between vitamin D receptor gene polymorphism and TB. This meta-analysis shows that
VDR FokI polymorphism pays to the hazard of pulmonary TB.
