Discovery of Novel
Antimalarial Agents: In vitro Biological Evaluation of a Series of Rhodanine Analogues
Firdaus Suffian Farah Yasmin, Senthil Kumar Priadarsshini, Sritharan Sharanya K,
Wong Yu Wan, Khaw Loke Tim and Avupati Vasudeva Rao
Res. J. Biotech.; Vol. 20(1); 50-54;
doi: https://doi.org/10.25303/201rjbt050054; (2025)
Abstract
Discovery of novel antimalarial agents is in urgent demand due to the global emergence
of Plasmodium falciparum resistant malaria against first-line drugs. In line with
the demand, we studied in vitro antimalarial properties of a series of rhodanine
analogues (C-C13) for their bioactive potential against P falciparum. Based on the
analysis of screening results and structure-activity relationship (SAR), C11 was
found to be a promising bioactive hit molecule (IC50: 4.755 μM).
