Probiotic Strain
Lactobacillus fermentum as a Potential Agent for the Reversal of Non-Periodontal
Microorganisms Induced Cognitive Dysfunctions
Murugan Mukilan
Res. J. Biotech.; Vol. 20(1); 55-68;
doi: https://doi.org/10.25303/201rjbt055068; (2025)
Abstract
The gastrointestinal tract of mammals consists of trillions of microorganisms including
beneficial and non-beneficial floras termed as gut microflora. These beneficial
gut microfloras are responsible for maintaining homeostasis mechanism of physiological
functions including cognitive health. However, disturbance in this gut microflora
results in the formation of gut dysbiosis. Gut dysbiosis results in the reduced
synthesis and transport of neurotransmitter precursor compounds from the gut to
the brain which causes impairment in the synthesis of neurotransmitters. The reduced
synthesis of neurotransmitters further results in impaired cognitive memory formation.
Formed cognitive impairment was reversed with the help of probiotic microorganisms.
The present study explored the positive role of the probiotic strain Lactobacillus
fermentum in the reversal of non-periodontal microorganisms (NPMs) induced cognitive
impairment.
For identifying the effect of L. fermentum on the reversal of cognitive impairment,
a three-phased behavioral analysis was used in the study. Behavioral studies were
carried out for all experimental groups in different scenarios including a serene
habituated environment with NPMs infusions and with L. fermentum infusions. Behavioral
responses showed that a stress-free habituated environment plays a major role in
the development of cognitive memory during the initial phase of behavioral analysis
(IPBA). In mid phase of behavioral analysis (MPBA), IPBA-formed cognitive memory
was impaired by the infusions of NPMs. Collective behavioral analysis proved that
probiotic oral infusions in final phase of behavioral analysis (FPBA) played a major
role in the reversal of induced cognitive impairment in experimental groups that
received oral infusions of NPMs.
