Topical Adipose
Mesenchymal Stem Cell Secretome Cream Improves Wound Healing in Partial-Thickness
Burned Mice
Rahmadian Rizki, Isral Ghozi Natul, Raymond Benni and Ariliusra Zikril
Res. J. Biotech.; Vol. 20(1); 1-6;
doi: https://doi.org/10.25303/201rjbt0106; (2025)
Abstract
Burn injury has a high prevalence worldwide; it is estimated that there were nearly
9 million burn cases in 2019. This injury impacts the physical and mental well-being
of the patient, as well as their overall quality of life. This study aims to analyze
the therapeutical effect of Mesenchymal Stem Cells Secretome (MSCS) for partial-thickness
burn wounds. This research is experimental research with a Posttest-Only Control
Group Design. The sample consisted of 24 white mice divided into three groups: the
control group, the 1% silver sulfadiazine (SSD) group and the MSCS group. A histopathological
examination of the wound was performed by hematoxylin-eosin staining.
The average thickness measurement of the burn surface epidermis in the SSD and MSCS
treatment groups showed a thicker epidermis than the control group. The vascular
density in the granulation tissue of the SSD (35.63) and MSCS (34.00) treatment
groups decreased compared to the control group. The fibroblast density in the granulation
tissue of the SSD (66.75) and MSCS (70.25) treatment groups was reduced compared
to that of the control group. The inflammatory cell density in the granulation tissue
of the SSD (70.75) and MSCS (50.88) treatment groups decreased than the control
group. The administration of MSCS cream showed a better histopathological image
than the control and was comparable to SSD treatment groups.
