Geographical distribution
of HPV Genotypes and their association with Socio-demographic and Clinicopathological
parameters among Normal, Pre-cancer and Cervical Cancer women in Chennai, India:
A Cross-sectional study
Venkatapathy Santhi, Jayaraman Radhika, Sundararajan Suresh kumar, Subramanian Malliga
J. and Amitkumar Kalaivani
Res. J. Biotech.; Vol. 20(7); 125-133;
doi: https://doi.org/10.25303/207rjbt1250133; (2025)
Abstract
Carcinoma of uterine cervix is a major worldwide wellness problem. Chronic infection
with high-risk Human papillomavirus (HPV) is a major risk factor for the onset of
invasive cervical cancer. The aim of this study is to investigate the HPV genotype
distribution and its correlation with the socio demographic and clinic pathological
features among healthy, cervical pre-cancer and cancer women in a defined region
of Chennai, Tamilnadu, India. 160 cervical specimens consisting of 41 Squamous cell
carcinoma(SCC), 4 Adenocarcinoma(AC), 35 precancerous lesions (LSIL/HSIL) and 80
samples from normal women were selected to perform detection and genotyping of high-risk
HPV using PCR.
Out of 160 women, 80(50%) had normal Pap smear, 35(21.8%) had Precancerous lesions
and 45(28.1%) had invasive cervical carcinoma. Among 80 women with abnormal cytology
of cervix, HPV was found in 78 (97.5%) subjects. The predominant strains of HPV
were HPV16 (41.02%) and HPV18 (38.4%). Several research investigations conducted
in diverse geographical locations across India have demonstrated considerable variations
in the frequency of infections caused by HPV and its genotype diversity. The present
research provides a recent valuable baseline data regarding HPV distribution in
this studied group.
