Comparative study
of antioxidant and nitric oxide level with PSA level in prostate cancer
Kotian Greeshma B., Rao Chandrika, Vangalapati Bheemesh, Shenoy Radhika and Rajeshwari
A.
Res. J. Biotech.; Vol. 20(3); 44-48;
doi: https://doi.org/10.25303/203rjbt044048; (2025)
Abstract
Prostate cancer was the world's second most common malignancy after lung cancer
accounting for 1,276,106 new cases and 358,989 fatalities (3.8% of all cancer-related
deaths in males) in 2018. Prostate cancer incidence and fatality rates globally
increase with age, with the average age at diagnosis being 66 years. According to
reports, prostate cancer is commonly associated with a shift in the oxidant/antioxidant
balance which results in increased oxidative stress. The present study aimed to
check the levels of antioxidants and nitric oxide in prostate cancer. The Ethics
Committee of Nitte (Deemed to be University) approved this study.
Blood samples were collected from 30 male patients with prostate cancer and 30 healthy
volunteers. 5 ml blood samples were collected in a clean tube and 2.5 ml of serum
was used for the estimation of total antioxidant (TAC), superoxide dismutase (SOD)
and nitric oxide (NO) levels. The TAC was estimated by phosphomolybdenum method.
SOD and NO in the sample were analyzed by spectrophotometric method. The current
study found that greater levels of oxidative damage and changes in the antioxidant
defence system in high-risk individuals may suggest a relationship between oxidative
stress and prostate cancer.
