Review Paper:
Irisin on Health
and Disease across Different Organ Systems-A Comprehensive Review
Sheela Joice P.P., Kothai Ramalingam, Suganthi V. and Dhas Priya K.
Res. J. Biotech.; Vol. 20(3); 222-226;
doi: https://doi.org/10.25303/203rjbt2220226; (2025)
Abstract
Irisin, a myokine discovered in 2012, has emerged as a multifaceted hormone with
far-reaching implications for human health and disease. Irisin's influence extends
to metabolic regulation where it plays a crucial role in energy expenditure, glucose
homeostasis and the browning of white adipose tissue. Named after the Greek messenger
goddess Iris, Irisin serves as a molecular communicator, transmitting signals of
physical activity and metabolic well-being throughout the body. Initially thought
to primarily affect skeletal muscle physiology, intriguingly, Irisin is not solely
the product of skeletal muscles but is secreted by various other tissues including
adipose tissue, the brain and the liver.
The central nervous system's regulation of irisin production has implications for
neurodegenerative diseases, cognitive function and mood disorders. Additionally,
we discuss the clinical applications and therapeutic potential associated with modulating
irisin levels. Understanding the multifaceted role of irisin in health and disease
has opened new avenues for interventions and therapies to enhance human well-being.
This review provides a comprehensive overview of irisin's diverse roles, shedding
light on its profound impact on health and disease.
