Evaluating the
in vitro inhibitory against Acne vulgaris activity of four medicinal plants (Cassia
grandis L.f., Houttuynia cordata Thunb., Piper betle L. and Hibiscus tiliaceus L.)
Thu Thi Cam Pham, Vy Huynh Phuong Bui, Phuong Ngo Diem Quach and Tan Quoc Tran
Res. J. Biotech.; Vol. 20(5); 45-54;
doi: https://doi.org/10.25303/205rjbt45054; (2025)
Abstract
Globally, Acne vulgaris is a chronic skin disease that significantly impacts people,
especially teenagers and young adults. Recent studies have focused on natural plant-based
materials that do not have the adverse effects of conventional medicines. This study
aimed to evaluate the in vitro inhibitory activity of extracts from Cassia grandis,
Houttuynia cordata, Piper betle and Hibiscus tiliaceus against Acne vulgaris. The
results showed that C. grandis and P. betle are promising materials for antibacterial
activity. The leaves of C. grandis exhibited the strongest antibacterial activity
in the agar disk diffusion method, with antibacterial ring diameters of 17.67 mm
and 19.33 mm corresponding to Cutibacterium acnes and Staphylococcus epidermidis
respectively. The stem and leaves of P. betle showed the strongest antibacterial
activity in the broth dilution method, with MIC=2.5 mg/mL. The leaves and stems
of C. grandis can inhibit the biofilm formation of C. acnes bacteria after 72 and
96 hours of investigation. Additionally, the extracts from C. grandis and P. betle
demonstrated different antioxidant and anti-inflammatory properties compared to
the other extracts in this study. The findings suggest that these plant extracts
have potential as a source of natural compounds for the treatment of Acne vulgaris.
