Comparison of
Serological and Hematological markers in Dengue: A Cross-sectional study
Balaji Vignesh Kanna, Sekar Jayapradha and Indernath Sunil
Res. J. Biotech.; Vol. 20(11); 150-153;
doi: https://doi.org/10.25303/2011rjbt1500153; (2025)
Abstract
Dengue virus is the most common Arbo-virus found in India. It has four serotypes
DEN-1 to DEN-4. Recently the fifth serotype (DEN-5) was discovered in 2013 from
Bangkok. Dengue is one of the major causes of mortality and morbidity in India.
Dengue is characterized by high fever, arthralgia, myalgia, hepatomegaly, and thrombocytopenia.
Early diagnosis of dengue leads to decrease the mortality. Our study aimed to explore
the early diagnostic methods for dengue fever. This is a cross sectional study conducted
in Department of Microbiology in a period of April 2021-March 2022. Simultaneously
blood samples were subjected to serological examination of NS1 antigen, IgM and
IgG antibody by immune-chromatographic method and hematological examination by auto-analyser.
Totally 382 patients were suspected to dengue; on this 74 were serologically proven.
Hematological investigation of patients shows thrombocytopenia, leucopenia, and
raised hematocrit. On correlation, hematological investigation is better in early
diagnosis of dengue fever (p value 0.014). Hematological investigation followed
by serology will lead to early diagnosis of dengue fever. Dengue fever is an important
public health problem in tropical countries like India. It can present varied clinical
manifestations. Early recognition and prompt management are essential to reduce
the morbidity and mortality associated with dengue.
