Genetic Pathway
Analysis of Inattentive Disorder Symptoms: A GWAS Study Analysis
Dinesh P., Adiga Usha, Jayapriya T., Vasishta Sampara and Manikyam M.
Res. J. Biotech.; Vol. 20(11); 76-84;
doi: https://doi.org/10.25303/2011rjbt076084; (2025)
Abstract
Inattentive disorders represent a significant public health concern with substantial
heritability, yet the specific genetic pathways underlying these conditions remain
inadequately characterized. This study aimed to identify and analyse genetic variants
associated with inattentive disorder symptoms through genome-wide association studies
(GWAS) and subsequent pathway enrichment analysis. GWAS data from previous studies
on inattentive disorder symptoms were extracted and mapped to genes. Comprehensive
enrichment analyses were conducted using multiple databases including Cell Marker,
Gene Ontology, KEGG, HMDB Metabolites, miRTarBase, PPI Hub Proteins and Reactome
Pathways to identify biological pathways significantly associated with candidate
genes.
Ten genes were identified as significantly associated with inattentive disorder
symptoms, including NOS1, GUCY1A2, PTCH1, PTPRN2, SLCO3A1, IL16, SPATA13, ZMAT4,
DNAJB6 and ZNF423. Pathway analyses revealed significant enrichment in nitric oxide
signaling, calcium ion regulation, hedgehog signaling pathway and neuron-specific
cellular components. The most statistically significant pathway was nitric oxide
stimulation of guanylate cyclase (p=0.0002621, adjusted p=0.0115). This study identifies
novel genetic pathways potentially involved in the pathophysiology of inattentive
disorders, particularly highlighting the role of nitric oxide signaling and calcium
ion regulation. These findings provide promising targets for further investigation
and potential therapeutic interventions for inattentive disorders.
