In type 1 DM,
Uric Acid as the early predictor of diabetic complications compared to microalbuminuria
Vidya Sagar G.V. and Ravi B.V.
Res. J. Biotech.; Vol. 20(10); 206-211;
doi: https://doi.org/10.25303/2010rjbt2060211; (2025)
Abstract
There is constant search for an early marker for diabetic complications. Microalbuminuria
[MA] is recognized as the early predictor of diabetic nephropathy [DN]. Increased
levels of serum uric acid [SUA] can be seen in later part of diabetes at the onset
of complications. This study was done to know the significance of SUA levels when
compared with MA in type 1 Diabetes Mellitus [DM] patients. Microalbuminuria was
estimated and compared with serum uric acid levels along with diabetic duration
and HbA1c.
Our results showed significantly increased mean levels of serum uric acid along
with microalbuminuria in type 1 diabetes. Uric acid and microalbuminuria were also
significantly increased in diabetes with >10 years duration and with HbA1c >10.
It is emphasized that SUA levels increase with the tissue injury, consequence of
glomerular basement membrane damage eventually leading to microalbuminuria. Hence
uric acid can be one of the early predictor along with microalbumnuria in early
onset of complications like nephropathy. It may also be used as prognostic marker
of diabetic complications in type 1 diabetes mellitus.
