The Influence
of AMHR II Polymorphisms on Infertility: A Comprehensive Study of A10G/rs11170555
and G4952A/rs3741664 in South Indian Women
Asra Anjum and Senthil Kumar B.
Res. J. Biotech.; Vol. 20(10); 29-34;
doi: https://doi.org/10.25303/2010rjbt029034; (2025)
Abstract
Infertility, affecting up to 15% of couples globally, often remains unexplained.
AMH (Anti-Müllerian Hormone) along with its corresponding receptor AMHR 2 play crucial
roles in ovarian follicular development. Genetic polymorphisms in the AMHR II gene,
specifically A10G (rs11170555) and G4952A (rs3741664), may influence fertility.
This study investigates the association between AMHR II polymorphisms and infertility
in South Indian women. Non experimental study involving 120 women with unexplained
infertility was conducted. Genomic DNA was extracted from the peripheral blood samples
obtained from all participants. Genotyping of rs11170555 and rs3741664 was performed
using Real-Time PCR.
The study identified specific genotypes as more prevalent in the population, with
some variations in allele distribution compared to previous studies. Recognizing
the distribution of these genotypes can help to identify individuals who might be
at risk of infertility linked to these polymorphisms. AMHR II polymorphisms show
significant variability, influencing reproductive outcomes. Understanding these
differences could enhance personalized infertility treatments. Additional studies
are needed to investigatethe effects on the functionality of these polymorphisms.
