Review Paper:
The Role of TP53
Mutations in Lung Cancer: Molecular Mechanisms, Therapeutic Implications and Future
Directions
Muthu Kumar Thirunavukkarasu
Res. J. Biotech.; Vol. 20(10); 340-344;
doi: https://doi.org/10.25303/2010rjbt3400344; (2025)
Abstract
Lung cancer is the most common in the world with multifaceted and diverse molecular
etiology. Lung cancer initiation, progression and metastasis are orchestrated by
a network of enzymes and proteins. They include TP53, KRAS, EGFR and ALK, which
are expressed and mutated at abnormally high levels. These molecules control signaling
in various cellular pathways including growth, survival, differentiation and invasion.
This review focuses on the malignantly regulated TP53, which is commonly and mutated
most frequently in non-small cell lung cancer Overall, we also highlighted the role
of TP53 in lung cancer development, the existing therapeutic approaches against
TP53 and its relation about the efficacy and adverse events such as resistance and
side effects and the next steps to achieve better outcomes in TP53 -positive lung
cancer patients.
