Media Optimization
for the production of lipopeptide from Streptomyces iconiensis VR1 Strain
Shobana R. and Ranjitha J.
Res. J. Biotech.; Vol. 20(9); 206-211;
doi: https://doi.org/10.25303/209rjbt2060211; (2025)
Abstract
This study reports a suitable culture medium for lipopeptide production using different
nitrogen and carbon sources. Lipopeptide was produced from Streptomyces iconiensis
VR1 Strain isolated from a soil sample. Sorbitol was the most suitable carbon source,
compared to glucose, starch, fructose, maltose and sucrose. The beef extract was
found to be a potential source of nitrogen for lipopeptide production. Therefore,
a pH of 7, temperature of 30(°C) and time (72h) showed maximum lipopeptide production
yield.
The lipopeptide extract obtained from streptomyces icoiniensis showed the highest
antifungal activity against Mucor sp. with 70.8 ± 2.6% and Aspergillus niger 45.3
± 1.5% of zone inhibition. Lipopeptide extract showed significant cell viability
(94.68 ± 2.2%) at 75 g/mL against Human cervical HT-3 cancer cells.
