Antifertility
effects of aqueous flower extract of Hibiscus rosa-sinensis (Linn.) on seminal parameters
in male Swiss albino mice.
Anand Nidhi, Sardar Raj Kumar, Anand Jany, Reja SK Jasim and Kumar Rajesh
Res. J. Biotech.; Vol. 21(2); 219-223;
doi: https://doi.org/10.25303/212rjbt2190223; (2026)
Abstract
This study was undertaken to investigate the antifertility effects of aqueous flower
extract of Hibiscus rosa-sinensis on seminal parameters in male Swiss albino mice.
The treated group of mice was administered 0.1 ml of aqueous flower extract of H.
rosa-sinensis orally with a gastric catheter at the dose of 200 mg/kg body weight
for 15, 30, 45 and 60 days, while the control group of mice was fed with 0.1 ml
of glass distilled water for the same exposure days. The mice were sacrificed through
the cervical dislocation method. Various physical parameters including sperm count,
sperm motility, seminal pH, sperm mortality and abnormality of spermatozoa were
assessed. For statistical analysis of data, the student’s t-test was applied.
The result demonstrated a significant decrease (P<0.001) in sperm count, sperm motility
and seminal pH in the treated group as compared to the control group of mice, while
significant (P<0.001) increases in sperm mortality and abnormal sperm morphology
were also observed in the treated group of mice as compared to the control group
of mice. These findings suggest that H. rosa-sinensis has a pronounced antifertility
effect in male Swiss albino mice, primarily through its impact on spermatogenesis
and hormonal balance. Thus, H. rosa-sinensis can be used as safe, cheaper, herbal,
reversible contraceptive agents for males.
