Harnessing Albizzia
lebbeck Leaf Extract for Phytofabricated Silver Nanoparticles with Thrombolytic,
Anticancer and Antioxidant Properties
Rathish Kumar S., Helan Soundra Rani M., Aswini A. and Gogul Ramnath M.
Res. J. Biotech.; Vol. 21(1); 52-62;
doi: https://doi.org/10.25303/211rjbt052062; (2026)
Abstract
The aqueous extract of Albizzia lebbeck was used to synthesize Ag NPs and was characterized
using UV-visible spectroscopy, FTIR analysis, XRD and FE-SEM, respectively. The
agent proves to be an effective antibacterial, antioxidant and anticancer treatment.
UV-visible spectroscopy analysis demonstrates a peak at λmax 422 nm, confirming
the successful reduction of silver ions to elemental Ag nanoparticles (Ag NPs).
Furthermore, FTIR analysis unequivocally validates the presence of biological moieties
involved in the synthesis process. XRD and FESEM inferred that the crystalline size
of the synthesized Ag NPs was 28nm and was spherical in appearance.
The nanoparticles showed promising inhibitory and dose-dependent activity on the
Gram-positive and Gram-negative bacteria. A simple and rapid in vitro clot lysis
model was employed to conduct the thrombolytic activity which revealed 47% clot
lysis. Ag NPs exhibited cytotoxic effects on prostate cancer cells at concentrations
(12, 25 and 55 μg/mL), with an IC50 value of 51.5 μg/mL. The results of this study
suggest that A. lebbeck Ag NPs have remarkable potential multipotent drug activities
and could be considered for future therapeutic applications after further analysis.
