Identification
of possible Anti-Alzheimer Mechanism of ginkgo biloba extract ‘EGB761’ using molecular
docking technique
Sahu Pratap Kumar, Prusty Shakti Ketan, Acharjee Hyking and Bose Anindya
Res. J. Biotech.; Vol. 21(1); 163-171;
doi: https://doi.org/10.25303/211rjbt1630171; (2026)
Abstract
Ginkgo biloba exerts (EGb761) is an effective and popular herbal medicine in patients
with Alzheimer's disease; however, its exact mechanism of action remains uncertain.
This study aims to investigate the role of phytoconstituents of G. biloba extract
in treating Alzheimer's disease. The major Alzheimer's disease related target proteins
are systematically investigated for their possible molecular interaction with major
active constituents of G. biloba using molecular docking techniques in silico.
The results indicated that the protective effects of G. biloba extract on Alzheimer's
disease may be a result of the synergistic effect of its various phytoconstituents
on multiple Alzheimer's disease targets, with most of the active compounds most
efficiently interacting with acetylcholinesterase and butyrylcholinesterase. The
findings of this study enhance our understanding of the molecular mechanism of G.
biloba extract in Alzheimer's disease and provide valuable insights for the future
development of therapeutic strategies.
