Review Paper:
MiR-21: Driving
lung cancer progression through hallmarks and its therapeutic potential
Savaram Sai Saatvika, Dharshini Loganathan Chandramani Priya and Mandal Abul Kalam
Azad
Res. J. Biotech.; Vol. 21(1); 376-383;
doi: https://doi.org/10.25303/211rjbt3760383; (2026)
Abstract
Lung cancer, a leading cause of cancer-related mortality globally, poses significant
challenges due to its varied subtypes and limited treatment options. miR-21, a microRNA
with oncogenic properties, plays a crucial role in various cellular processes essential
for cancer progression. This review delves into the role of miR-21 in lung cancer
progression, highlighting its regulation of key cancer cell functions such as sustaining
proliferative signaling, evading growth suppressors, resisting apoptosis, enabling
limitless replication, inducing angiogenesis and promoting invasion and metastasis.
Furthermore, miR-21’s impact on immune regulation underscores its potential as a
therapeutic target. By targeting miR-21, researchers aim to develop innovative strategies
to enhance treatment outcomes for lung cancer patients.
