Anticancer Potential
of Novel Amide Derivatives of Pyrido-thiazolo[5,4-b] pyridine: Synthesis and Biological
Evaluation
Matta Manikanttha, Bhuvan Tej Mandava, Reddy Nithyanand, Deepti Kolli and Mandava
Venkata Basaveswara Rao
Res. J. Chem. Environ.; Vol. 29(8); 21-29;
doi: https://doi.org/10.25303/298rjce021029; (2025)
Abstract
A new library of amide derivatives of pyridothiazolo[ 5,4-b] pyridine (11a-j) was
designed, synthesized and their chemical structures were confirmed by spectral data
and analytical data. Further, all these newly synthesized compounds 11a-j were tested
for their preliminary anticancer applications against a panel of human cancer cell
lines such as breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205)
and ovarian cancer (A2780) by using of MTT assay and the obtained results were compared
with known chemotherapeutic agents namely etoposide used as positive control.
Most of the tested compounds displayed good to moderate anticancer properties on
all cell lines. Among them, five compounds, 11a, 11b, 11c, 11d and 11e, exhibited
more potent activity as compared to etoposide, in which one of the compounds, 11a,
displayed superior activity.
