Formulation and
evaluation of mucoadhesive microspheres of lisinopril, an antihypertensive drug
Ravikiran T. Naga, Madhulatha A.V.S., Himabindu A.V.S., Bhargavi M. and Jaya Vasavi
G.
Res. J. Chem. Environ.; Vol. 29(8); 87-100;
doi: https://doi.org/10.25303/298rjce0870100; (2025)
Abstract
The objective of this research work is to develop and evaluate mucoadhesive microspheres
of an anti-hypertensive drug for sustained release. Mucoadhesive microspheres were
prepared by emulsification method using sodium alginate, HPMC K4M, HPMC K100M, Na
CMC, carbopol 974P and chitosan in the various drug-polymer ratios. Six formulations
were formulated and evaluated for possible drug polymer interactions, percentage
yield, micromeritic properties, particle size, drug content, drug entrapment efficiency,
drug loading, swelling index, in vitro wash off test, in vitro drug release, surface
morphology and release kinetics.
The results showed no significant drug polymer interaction in FTIR studies. Among
all the formulations, F4 containing HPMC K100M showed 99.51% drug release in 24
hrs. Amongst the developed mucoadhesive microspheres, F4 formulation containing
HPMC K100M exhibited slow and sustained release in a controlled manner and it is
a promising formulation for sustained release of Lisinopril.
