Michael reaction
of indoles with alpha, beta unsaturated carbonyl compounds by using environmental
benign reagent DIB
Phani R.S. CH, Dakshayini, Chaitanya Darapureddy, Vardhana Syamala and Umamaheswar
Korr
Res. J. Chem. Environ.; Vol. 29(12); 118-130;
doi: https://doi.org/10.25303/2912rjce1180130; (2025)
Abstract
The Michael addition reaction represents a pivotal strategy for carbon–carbon bond
formation in organic synthesis. In this study, we report a green and efficient protocol
for the Michael reaction of indoles with α,β- unsaturated carbonyl compounds utilizing
the environmentally benign reagent 1,3-dibromo-5,5- dimethylhydantoin (DIB).
This method offers a mild, solvent-free and metal-free approach, promoting high
yields and regioselectivity under ambient conditions. The use of DIB not only facilitates
the reaction but also aligns with principles of green chemistry by minimizing hazardous
waste and energy consumption. This protocol demonstrates broad substrate scope and
operational simplicity, rendering it an attractive alternative for sustainable synthesis
in heterocyclic chemistry.
