Synthesis, Characterization
and Antimicrobial Activity of Novel 2H-oxazinyl-thiazolidinone-4 and 2H-oxazinyl-3(4H))-4-methylbenzo[h]
quinolinone-2(1H)Derivatives
Tripathi Ajay Kumar, Awasthi Anoop K., Tiwari Ram Prakash, Srivastava Ashutosh K.
and Srivastava Krishna
Res. J. Chem. Environ.; Vol. 29(12); 46-55;
doi: https://doi.org/10.25303/2912rjce046055; (2025)
Abstract
The synthesis of effective biomaterial works as antimicrobial agent. A series of
-thiazolidin-4-one and -oxoazetidin-2-yl- derivatives were easily obtained commencing
from α-naphthol and ethyl acetoacetate to form coumarin and then converted into
-quinolin-2(1H)-one using hydrazine hydrate followed by subsequent reaction of quinolin-2(1H)-one
and p-hydroxy benzaldehyde oxazine-6-carbaldehyde Thereafter carbaldehyde and aromatic
primary amine were condensed from imines.
Final cyclized derivatives were achieved by the reaction of imine with thioglycollic
acid and chloroacetyl chloride. The structure elucidation of all the novel derivatives
was accomplished through PMR, Mass and IR studies. The antimicrobial activity was
assessed in vitro by serial dilution method. The activity of 5(b,d,g) and 6(b,f,g)derivatives
showed noticeable antimicrobial activity against the tested microbes.
