Review Paper:
Heterocyclic Schiff
Base and their Metal Complexes: A Review on Antibacterial and Antifungal Activities
Gupta Akhilesh Kumar
Res. J. Chem. Environ.; Vol. 29(3); 133-147;
doi: https://doi.org/10.25303/293rjce1330147; (2025)
Abstract
Schiff’s bases are well-known organic compounds for the synthesis of new “Metal
based Drugs” and are synthesized by condensation reaction of different hydrazide
or hydrazine with aldehydes or ketones known as imines. Schiff bases and their metal
complexes have received remarkable attention among inorganic chemistry researchers
due to their unique properties and applications in various fields. They are acting
as main source of medicinal compounds displaying anti-inflammatory, antitumor, anticancer,
antimalarial, antiviral, anthelmintic and antimicrobial properties in addition to
industrial application as food packages, dyes and polymers. Various studies indicate
that bioactive compounds having trace amounts of metal ions enhanced their potential
to fight against pathogens. Lack of metal ions is causing many diseases including
anemia, decrease in growth and cardiovascular disease amongst children. It is sort
out by studying new approaches and new action of mechanism improving the efficiency
of the drugs.
Currently, researchers and professional are paying lots of efforts to use Schiff
base metal complexes to cure several diseases which are difficult to treat with
traditional methods. Metal complexes enhances biological activities and acting as
bridge between conventional inorganic and organic compounds. Keeping in mind above
mentioned facts, review paper demonstrated mainly on the current pharmacological
innovation in the field of synthesis, structural, antimicrobial applications of
Schiff bases.
