Synthesis, in
silico analysis and antidepressant activity of 1,3,4-oxadiazole derivatives
Anjanaraj, Deshpande Shridhar N., Anagha and Revanasiddappa B.C.
Res. J. Chem. Environ.; Vol. 29(3); 1-6;
doi: https://doi.org/10.25303/293rjce0106; (2025)
Abstract
A new class of 1,3,4-oxadiazole derivatives (O1-4) was synthesized and physically
characterized by using spectroscopic (IR, 1H-NMR, Mass) methods. In silico studies
were performed for all the new compounds and were put through ADME screening with
Schrodinger suite 2020-4. Some of the compounds were tested for in vivo antidepressant
efficacy utilizing the Forced swimming test and Tail suspension test. The final
1,3,4-oxadiazole analogues can potentially be developed into viable antidepressant
drugs and might be beneficial as lead compound for pharmaceutical firms based on
the in silico and in vivo research.
