Effective synthesis
and pharmacological evaluation of 1,2,4-triazolo-isoxazole and 1,2,4-triazolo-pyrazole
scaffolds
Sharma Aruna, Yadav Anjali, Pathak Hardik, Jangir Bhawana and Goel Rahul
Res. J. Chem. Environ.; Vol. 29(5); 77-82;
doi: https://doi.org/10.25303/295rjce077082; (2025)
Abstract
Five-membered heteroaromatic compounds like pyrazoles and isoxazoles are significant
for the pharmaceutical sector and material research, becoming more significant in
drug research, cosmetics as well as in the creation of agricultural products. 1,2,4-triazolo
fused isoxazole derivatives (3a-f) were synthesized from reaction between intermediate
chal cone-1,2,4-triazolo-1,5-benzodiazepine derivatives 2af with hydroxyl amine
hydrochloride. 1,2,4-triazolo fused pyrazole derivatives (3a-f and 4a-f) were prepared
from reaction between chalcone derivatives 2a-f with hydrazine hydrate and its phenyl
derivatives respectively in high yields.
Synthesized isoxazoles and pyrimidine derivatives have broad spectrum of medicinal
importance. These pharmacophoric scaffolds represent a class of antimicrobial screening
for Candida albicans, Staphylococcus aureus, Enterobacter cloacae, Fusarium oxysporum
and Escherichia coli.
