Fabrication and
characterization wound dressing form silk fibroin/curcumin film incorporating natural
oil
Vu Nguyen Doan and Ha Le Bao Tran
Res. J. Chem. Environ.; Vol. 29(5); 169-176;
doi: https://doi.org/10.25303/295rjce1690176; (2025)
Abstract
Nowadays, silk fibroin is widely applied in many biomedical researches including
the potential research field in fabricating wound dressings. Curcumin which is traditional
herbal, has many suitable features for treatment of skin loss lesions such as antiinflammatory,
antibacterial, antifungal, especially reducing formation of scars and improvable
wound healing. Furthermore, the incorporation of natural oils improves the physical
properties of the fibroin/curcumin film. In this research, silk sericin is degummed
by high temperature alkaline solution to collect fibroin fibers. Fibroin fibers
and curcumin flour are dissolved by 98% formic acid supplement calcium chloride.
Then coconut oil is added to the final mixture with concentrations 0.4%, 0.6% (v/v)
respectively.
Fabricated fibroin/curcumin films (FCF) are evaluated with properties such as morphology
surface, mechanical tensile, water uptake, water vapor transmission rate, biodegradation
capability, pH changing, preventing bacteria penetration capability and in vitro
cytotoxicity test. All results showed that FCFs prepared with different concentrations
of coconut oil met all the required properties of wound dressings. This research
is the initial step in creating the foundation and direction for the development
of commercial silk wound dressings.
