Synthesis, Characterization,
and Molecular Docking Studies of Zinc (II) Metal Complexes with Some New Biologically
Active Schiff Base Ligands
Bharati Gyanendra Kumar, Srivastava Vishnu Prabhakar and Srivastava Shekhar
Res. J. Chem. Environ.; Vol. 29(10); 95-105;
doi: https://doi.org/10.25303/2910rjce0950105; (2025)
Abstract
Ten complexes of the type [ZnX2L21-5] (where X= Cl or Br and L = new Schiff base
ligands derived by condensation of 2-carbaldehyde-8-hydroxyquinonile and 2-amino-6-methylpyridine
or cyclopropylamine or 3-morpholine-4-ylpropylamine or 2-aminopyridine or homopiperonylamine)
have been prepared and characterized by elemental analysis, molar conductivity,
IR and XPS data i.e. X-ray photoelectron spectra. An octahedral geometry has been
proposed for all these prepared[ZnX2L21-5] complexes. Using two protein receptors,
the interaction between ligand and protein was investigated using molecular docking.
The proteins 7LDW and 6HV0 displayed binding energies of -6.5 and -7.8 kcal/mol
respectively, suggesting that they may find use in medicine. Further, pharmacological
actives based on 8-hydroxyquinoline-2-carbaldehyde and homopiperonylamine may benefit
from this study.
