pH-Responsive
Hydrogel of Poly(2-Hydroxyethyl Acrylate-Co-2-Acrylamido-2-Methyl-1-Propane Sulphonic
Acid-Co-Ethylene Glycol Vinyl Ether): Synthesis, Diffusion Characteristics and Drug
Delivery Applications
Lakshminarayana Vollu, Reddy KVN Suresh, Jalababu Ramani and Rao KSV Krishna
Res. J. Chem. Environ.; Vol. 29(10); 12-22;
doi: https://doi.org/10.25303/2910rjce012022; (2025)
Abstract
This study reports the preparation of pH-responsive hydrogels for the controlled
release of the non-steroidal anti-inflammatory drug Tapentadol HCl (TPCL). The hydrogels
were synthesized through cross-linking of 2-hydroxyethyl acrylate (HEA) and (1,1-Dimethyl-2-sulfoethyl)acrylamide,
2-Acrylamido-2-methylpropane sulfonic acid) (AMPS) with ethylene glycol vinyl ether
(EGVE) using N,N′-methylenebis(acrylamide) (NN-MBA) via free radical polymerization.
To elucidate the characterization properties of the hydrogels, FTIR, DSC, XRD and
SEM techniques were employed. Diffusion characteristics of hydrogels were evaluated
by calculating network parameters. Dynamic swelling and drug release patterns of
hydrogels were assessed in pH 1.2 and 7.4 phosphate buffer solutions, with results
indicating slight enhanced swelling and drug release in pH 7.4 at 24 hours.
