Deep eutectic
solvent mediated synthesis of pyrazolo[3,4-b]- and pyrimido[4,5-b]quinolines
Jadhav Siddheshwar D., Kashid Vitthalrao S., Patil Dattatray V. and Yedage Dattatray
B.
Res. J. Chem. Environ.; Vol. 29(9); 18-24;
doi: https://doi.org/10.25303/299rjce018024; (2025)
Abstract
Herein, this research explores the versatility and efficiency of choline chloride
based deep eutectic solvent (DES) as a catalyst as well as reaction media for the
cyclocondensation of pyrazolo[3,4-b]quinolines and pyrimido[4,5-b]quinolines. The
eutectic solvent employed for this protocol is recyclable, non-toxic, non-volatile
and biodegradable with high chemical and thermal stability, making it ideal for
the sustainable synthesis of quinoline derivatives. These protocols are simple,
straightforward, highly scalable and aligned with green chemistry principles. Additionally,
these methods are eco-friendly, economical and outperform existing methodologies
in operational efficiency.
