Microwave-Assisted
Synthesis of 2-Chloroquinoline-3-Carbaldehyde on Silica Support using Mild Acidic
Charcoal Catalyst
Chavan Jagdish, Patil Rajendra, Patel Shivnath, Shinde Sachin and Beldar Anil
Res. J. Chem. Environ.; Vol. 29(9); 25-29;
doi: https://doi.org/10.25303/299rjce025029; (2025)
Abstract
2-Chloroquinoline-3-carbaldehyde was synthesized using a silica-supported reaction
system with a mildly acidic charcoal catalyst under microwave irradiation. The aim
of optimizing the catalytic process was to improve both the yield and efficiency
of the reaction. The use of microwave irradiation significantly shortened the reaction
time while the mildly acidic charcoal created an effective and environmentally friendly
catalytic environment.
The reaction proceeded smoothly, producing substantial amounts of the desired 2-chloroquinoline-3-carbaldehyde,
which demonstrates the effectiveness of the silica-supported, charcoal-catalyzed
method. This approach provides a sustainable and efficient alternative for synthesizing
quinoline derivatives, which could have applications in pharmaceuticals and organic
synthesis.
