Unraveling the
Antiobesity Potential of Balanites aegyptiaca Leaves through Computational techniques
Sonavane Dhanashri, Shirode Devendra, Daswadkar Shubhangi, Gawande Gauri and Bhapkar
Jaydip
Res. J. Chem. Environ.; Vol. 29(9); 147-154;
doi: https://doi.org/10.25303/299rjce1470154; (2025)
Abstract
Obesity is a major health problem worldwide caused by the excessive accumulation
of body fat which is linked to cause various diseases such as diabetes, heart disease,
cancer and others. In this study, we used computational techniques (network pharmacology
and molecular docking) for Balanites aegyptiaca leaves (BAL) to treat obesity. Three
active compounds were identified by using network pharmacology which are: Quercetin,
Acacetin, Apigenin while obesity related targets genes were obtained from GeneCards
database. These genes are involved in fat metabolism, energy balance and inflammation.
Molecular docking showed strong binding affinity of these phytochemicals.
AKT1 is the most significant target for obesity. The 3Dimentional structure of AKT1
protein (PDB ID: 3O96) was retrieved from protein data bank which is optimized and
analyzed for its interactions. These findings suggest that Balanites aegyptiaca
leaves may help in obesity management by targeting key biological pathways. However,
further laboratory and clinical studies are needed to confirm effectiveness of Balanites
aegyptiaca leaves in the treatment of obesity.
